Introduction: Cognitive impairment in multiple sclerosis (MS) is increasingly being investigated with resting-state functional MRI (rs-fMRI) functional connectivity (FC). However, results remain difficult to interpret, showing both high and low FC associated with cognitive impairment. We conducted a systematic review of rs-fMRI studies in MS to understand whether the direction of FC change relates to cognitive dysfunction, and how this may be influenced by the choice of methodology.

中文翻译：

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多发性硬化症静息状态功能性 MRI 连接变化和认知障碍的系统评价

简介：多发性硬化症 (MS) 的认知障碍越来越多地通过静息状态功能 MRI (rs-fMRI) 功能连接 (FC) 进行研究。然而，结果仍然难以解释，显示高和低 FC 都与认知障碍相关。我们对 MS 中的 rs-fMRI 研究进行了系统回顾，以了解 FC 变化的方向是否与认知功能障碍有关，以及这可能如何受到方法选择的影响。