The nano-hydroxyapatite (nHAp) is widely used to develop imaging probes and drug carriers due to its excellent bioactivity and biocompatibility. However, traditional methods usually need cumbersome and stringent conditions such as high temperature and post-modification to prepare the functionalized nHAp, which do not benefit the particles to enter cells due to the increased particle size. Herein, a biomimetic synthesis strategy was explored to achieve the AS1411-targeted tumour dual-model bioimaging using DNA aptamer AS1411 as a template. Then, the imaging properties and the biocompatibility of the synthesized AS-nFAp:Gd/Tb were further investigated.

中文翻译：

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适体介导的多功能纳米羟基磷灰石合成用于活性肿瘤生物成像和治疗

纳米羟基磷灰石（nHAp）因其优异的生物活性和生物相容性而被广泛用于开发成像探针和药物载体。然而，传统方法通常需要繁琐和严格的条件，如高温和后修饰来制备功能化的 nHAp，由于粒径增加，这不利于颗粒进入细胞。在此，探索了一种仿生合成策略，以 DNA 适配体 AS1411 为模板实现 AS1411 靶向肿瘤双模型生物成像。然后，进一步研究了合成的 AS-nFAp:Gd/Tb 的成像特性和生物相容性。