Perforations are a rare but serious complication of colorectal cancer. The current standard of treatment is emergent surgery followed by adjuvant chemotherapy. The concern with this approach is not only the uncertainty of achieving a R0 resection but also potential injury to adjacent vessels, nerves and ureters due to inflamed tissue planes. A subset of this patient population with a contained perforation who are clinically stable may have superior oncological outcomes with local sepsis control, neoadjuvant therapy followed by radical resection. The aim of this study is to report on the pre-operative safety profile for neoadjuvant therapy in the setting of an abscess from colon cancer perforation and the short-term oncological surgical quality outcomes.

中文翻译：

---

新辅助治疗是局部穿孔结肠癌立即手术的替代策略吗？

穿孔是结直肠癌罕见但严重的并发症。目前的治疗标准是紧急手术，然后是辅助化疗。这种方法的担忧不仅在于实现 R0 切除的不确定性，而且还可能因组织平面发炎而对邻近血管、神经和输尿管造成伤害。在局部脓毒症控制、新辅助治疗和根治性切除术中，有一部分具有封闭性穿孔且临床稳定的患者可能具有更好的肿瘤学结果。本研究的目的是报告在结肠癌穿孔脓肿的情况下新辅助治疗的术前安全性概况和短期肿瘤手术质量结果。