Improved function and balance in T cell modulation by endothelial cells in young people,Clinical & Experimental Immunology

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Improved function and balance in T cell modulation by endothelial cells in young people
Clinical & Experimental Immunology ( IF 3.4 ) Pub Date : 2021-08-12 , DOI: 10.1111/cei.13654
Shu-Qian Tang ₁ , Wei-Li Yao ₁ , Ya-Zhe Wang ₁ , Yuan-Yuan Zhang ₁ , Hong-Yan Zhao ₁ , Qi Wen ₁ , Yu Wang ₁ , Lan-Ping Xu ₁ , Xiao-Hui Zhang ₁ , Xiao-Jun Huang ₁ , Yuan Kong ₁

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Elderly individuals exhibit unbalanced bone marrow (BM) effector T cell subset differentiation, such as increased T helper type 1 (Th1) and T cytotoxic type 1 (Tc1) cell frequencies, but the underlying mechanism is still unclear. Endothelial cells (ECs), which are instructive components of the BM microenvironment, exhibit the phenotype of semi-professional antigen-presenting cells and regulate T cell recruitment and activation. Thus, we compared the frequency and function of BM ECs, especially their capacity to regulate effector T cell subsets, between young and elderly healthy individuals, and explored the underlying mechanism of this immunomodulatory discrepancy. Although the young and elderly EC percentages were comparable, young ECs showed fewer reactive oxygen species and better migratory and tube-forming abilities than elderly ECs. Notably, increased T cell activation molecules and inflammatory cytokines were found in elderly ECs which regulated T cells to differentiate into more proinflammatory T cells, including Th1 and Tc1 cells, than young ECs.

中文翻译：

改善年轻人内皮细胞调节 T 细胞的功能和平衡

老年人表现出不平衡的骨髓 (BM) 效应 T 细胞亚群分化，例如 T 辅助 1 型 (Th1) 和 T 细胞毒性 1 型 (Tc1) 细胞频率增加，但其潜在机制仍不清楚。内皮细胞 (EC) 是 BM 微环境的指导性成分，表现出半专业抗原呈递细胞的表型并调节 T 细胞的募集和活化。因此，我们比较了年轻和老年健康个体之间 BM ECs 的频率和功能，尤其是它们调节效应 T 细胞亚群的能力，并探讨了这种免疫调节差异的潜在机制。尽管年轻和老年 EC 的百分比相当，但与老年 EC 相比，年轻 EC 的活性氧种类更少，迁移和管形成能力更好。尤其，

更新日期：2021-10-12

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