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ARTEMIS highlights VEGF inhibitors as effective partners for EGFR TKIs in EGFR mutant NSCLC
Cancer Cell ( IF 50.3 ) Pub Date : 2021-08-12 , DOI: 10.1016/j.ccell.2021.07.017
Xiuning Le 1 , Monique B Nilsson 1 , Jacqulyne P Robichaux 1 , John V Heymach 1
Affiliation  

The randomized ARTEMIS study demonstrates that adding the VEGF inhibitor bevacizumab to the EGFR inhibitor erlotinib improves progression-free survival in EGFR mutant non-small-cell lung cancer by more than 6 months, with even greater benefits seen in patients with brain metastases and EGFR L858R mutation. This provides further evidence for the tailored use of VEGF/EGFR combinations.



中文翻译:

ARTEMIS 强调 VEGF 抑制剂是 EGFR 突变 NSCLC 中 EGFR TKI 的有效合作伙伴

随机 ARTEMIS 研究表明,在 EGFR 抑制剂厄洛替尼中加入 VEGF 抑制剂贝伐单抗可将 EGFR 突变型非小细胞肺癌的无进展生存期提高 6 个月以上,在脑转移和 EGFR L858R 患者中的获益甚至更大突变。这为定制使用 VEGF/EGFR 组合提供了进一步的证据。

更新日期:2021-09-13
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