Methamphetamine withdrawal can induce intense cravings leading to relapse. Contexts/cues paired with chronic methamphetamine use develop incentive motivational properties, promoting future drug-seeking and taking behavior. Research has shown that, in adult male rats, the selective 5-HT_2A receptor antagonist M100907 attenuates the acquisition of methamphetamine-induced conditioned place preference (CPP), a measure that examines conditioned associations between the rewarding properties of drugs and contexts. However, these findings have not been extended to adult female rats. The present study investigated the effects of M100907 on the acquisition of methamphetamine-CPP in adult female rats. During conditioning, rats were administered M100907 (0, 0.025, 0.25 mg/kg, i.p.) 15 min before methamphetamine (1 mg/kg, i.p.) and then placed into their initially non-preferred chamber for 30 min, or administered saline and placed into their initially preferred chamber for 30 min. Conditioning sessions were separated by four hours. Following four days of conditioning, the effects of M100907 on the acquisition of methamphetamine-CPP were assessed during a 15 min drug-free test trial. Pretreatment with M100907 dose-dependently attenuated the acquisition of methamphetamine-induced CPP. Blocking 5-HT_2A receptors with a low dose of the selective antagonist M100907 attenuated the rewarding effects of methamphetamine in adult female rats. These data provide further evidence that the 5-HT_2A receptor subtype is involved in the behavioral effects of methamphetamine.

甲基苯丙胺戒断会引起强烈的渴望，从而导致复发。与慢性甲基苯丙胺使用配对的背景/线索会产生激励动机特性，促进未来的吸毒和吸毒行为。研究表明，在成年雄性大鼠中，选择性 5-HT _2A受体拮抗剂 M100907 减弱甲基苯丙胺诱导的条件性位置偏好 (CPP) 的获得，这是一种检查药物奖励特性和环境之间条件关联的措施。然而，这些发现尚未扩展到成年雌性大鼠。本研究调查了 M100907 对成年雌性大鼠获得甲基苯丙胺-CPP 的影响。在调节期间，在甲基苯丙胺（1 mg/kg，ip）前 15 分钟向大鼠施用 M100907（0、0.025、0.25 mg/kg，ip），然后将其放入最初不喜欢的室中 30 分钟，或施用盐水并放置进入他们最初首选的房间 30 分钟。调理课程相隔四个小时。经过四天的调理，在 15 分钟的无药物测试试验中评估了 M100907 对甲基苯丙胺-CPP 获得的影响。用 M100907 预处理剂量依赖性地减弱了甲基苯丙胺诱导的 CPP 的获得。阻断 5-HT具有低剂量选择性拮抗剂 M100907 的_{2A受体减弱了甲基苯丙胺对成年雌性大鼠的奖赏作用。}这些数据提供了5-HT _2A受体亚型参与甲基苯丙胺的行为影响的进一步证据。