Associations of telomere length at birth with predicted atherosclerotic lesions and cardiovascular disease risk factors in midlife: A 40-year longitudinal study,Atherosclerosis

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Associations of telomere length at birth with predicted atherosclerotic lesions and cardiovascular disease risk factors in midlife: A 40-year longitudinal study
Atherosclerosis ( IF 4.9 ) Pub Date : 2021-08-12 , DOI: 10.1016/j.atherosclerosis.2021.08.013
Zhongzheng Niu ₁ , Xiaozhong Wen ₂ , Stephen L Buka ₃ , Meng Wang ₄ , Lili Tian ₅ , Eric B Loucks ₃ , Laura D Kubzansky ₆ , Lina Mu ₁

Affiliation

Background and aims

Adult telomere length (TL) is substantially determined by birth TL, but associations of birth TL with cardiovascular disease (CVD) are unknown.

Methods

We included 144 adult offspring born in 1959–1966 from the Collaborative Perinatal Project, a US birth cohort. Birth TL was measured from banked cord blood with quantitative polymerase chain reaction. Atherosclerotic lesions were predicted by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) score that was based on blood pressure, lipids, hemoglobin A1c, and body weight at the midlife follow-up in 2003–2008 (average age: 42 years). Information on midlife CVD risk factors including the age at first diagnoses of hypertension, hypercholesterolemia, and diabetes was also collected. We used linear and logistic regression models to analyze associations of birth TL with the continuous PDAY score and categorical CVD risk factors, respectively, adjusting for prenatal confounders.

Results

At midlife follow-up, 31.2% and 18.7% of participants had ever been diagnosed with hypercholesterolemia and hypertension, respectively, and 8.3% met the criteria for metabolic syndrome. Short birth TL (Quartile 1, Q1) was associated with a higher PDAY score (adjusted β: 1.78, 95% CI: 0.31, 3.25), increased odds of hypercholesterolemia (adjusted odds ratio [OR]: 3.23, 95% CI: 1.28, 8.18) and the presence of any cardiometabolic abnormalities (adjusted OR: 2.54, 95% CI: 1.00, 6.48) as compared to longer birth TL (Q2-Q4) after adjusting for prenatal confounders.

Conclusions

People born with short TL may be at increased risk of predicted midlife atherosclerotic lesions and hypercholesterolemia. Future studies with larger sample sizes and CVD morbidities are warranted to replicate our findings.

中文翻译：

出生时端粒长度与预测的动脉粥样硬化病变和中年心血管疾病危险因素的关联：一项为期 40 年的纵向研究

背景和目标

成人端粒长度 (TL) 基本上由出生 TL 决定，但出生 TL 与心血管疾病 (CVD) 的关联尚不清楚。

方法

我们纳入了 144 名出生于 1959-1966 年的成年后代，这些后代来自美国出生队列协作围产期项目。出生 TL 是通过定量聚合酶链反应从储存的脐带血中测量的。动脉粥样硬化病变由青年动脉粥样硬化病理生物学决定因素 (PDAY) 评分预测，该评分基于 2003-2008 年中年随访时的血压、血脂、血红蛋白 A1c 和体重（平均年龄：42 岁）。还收集了有关中年 CVD 危险因素的信息，包括首次诊断出高血压、高胆固醇血症和糖尿病的年龄。我们使用线性和逻辑回归模型分别分析出生 TL 与连续 PDAY 评分和分类 CVD 风险因素的关联，调整产前混杂因素。

结果

在中年随访时，分别有 31.2% 和 18.7% 的参与者被诊断出患有高胆固醇血症和高血压，8.3% 的参与者符合代谢综合征的标准。短产 TL（第 1 季度，第 1 季度）与较高的 PDAY 评分（调整后β：1.78，95% CI：0.31，3.25）、高胆固醇血症几率增加（调整后优势比 [OR]：3.23，95% CI：1.28）相关, 8.18) 和任何心脏代谢异常的存在（调整后的 OR：2.54，95% CI：1.00，6.48）与调整产前混杂因素后的长出生 TL（Q2-Q4）相比。