Objective. The relationship between metabolic risk and ovarian function is ambiguous. This retrospective study analyzed the medical records of 461 PCOS patients collected between January 2019 and June 2020 to investigate the relationship between serum anti-Müllerian hormone (AMH) and parameters of metabolic risk in the population with polycystic ovary syndrome (PCOS). Methods. A total of 461 PCOS patients aged 20–40 years were included and stratified into four groups according to the AMH level. The association between AMH and the parameters related to metabolic risk in these groups was compared, and the discrepancies were further explored. Binary logistic regression was performed to examine the risk factors of HOMA-IR. The values of AMH that best predicted the risk of HOMA-IR were also analyzed by ROC curves. Results. AMH was negatively associated with HOMA-IR (odds ratio (OR) −0.279, 95% confidence interval (CI) −0.36 to −0.20), fasting insulin (OR −0.282, 95% CI −0.36 to −0.20), 1-hour postprandial insulin (OR −0.184, 95% CI −0.28 to −0.11), 2-hour postprandial insulin (−0.180, 95%CI −0.28 to −0.11), 3-hour postprandial insulin (OR −0.198, 95% CI –0.30 to −0.13), waist-hip ratio (OR −0.235, 95% CI −0.31 to −0.14), and body mass index (OR −0.350, 95% CI −0.43 to −0.27). There was no statistically significant relationship between blood pressure, serum glucose profile, or lipid levels and AMH. Binary logistic regression showed that AMH protected against the occurrence of PCOS patients (OR: 0.835, 0.776, and 0.898). For the prediction of HOMA-IR, AMH had an AUC-ROC of 0.704 (95% CI 0.652–0.755) with a cutoff value of 7.81 mmol/L, a sensitivity of 70.3%, and a specificity of 70.1%. Conclusions. Higher AMH levels were significantly associated with a lower insulin profile and might be a useful predictor for HOMA-IR in PCOS patients.

中文翻译：

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AMH 是 PCOS 女性代谢风险的良好预测指标：一项横断面研究

客观。代谢风险与卵巢功能之间的关系不明确。这项回顾性研究分析了 2019 年 1 月至 2020 年 6 月期间收集的 461 名 PCOS 患者的医疗记录，以研究血清抗苗勒管激素 (AMH) 与多囊卵巢综合征 (PCOS) 人群代谢风险参数之间的关系。方法. 共纳入 461 名 20-40 岁的 PCOS 患者，根据 AMH 水平分为四组。比较了这些组中 AMH 与代谢风险相关参数之间的关联，并进一步探讨了差异。进行二元逻辑回归以检查 HOMA-IR 的危险因素。还通过 ROC 曲线分析了最能预测 HOMA-IR 风险的 AMH 值。结果. AMH 与 HOMA-IR 呈负相关（优势比 (OR) -0.279, 95% 置信区间 (CI) -0.36 至 -0.20），空腹胰岛素（OR -0.282, 95% CI -0.36 至 -0.20），1-餐后一小时胰岛素 (OR -0.184, 95% CI -0.28 至 -0.11), 餐后 2 小时胰岛素 (-0.180, 95%CI -0.28 至 -0.11), 餐后 3 小时胰岛素 (OR -0.198, 95% CI –0.30 至 -0.13)、腰臀比 (OR -0.235, 95% CI -0.31 至 -0.14) 和体重指数 (OR -0.350, 95% CI -0.43 至 -0.27)。血压、血清葡萄糖谱或血脂水平与 AMH 之间没有统计学上的显着关系。二元逻辑回归显示 AMH 可预防 PCOS 患者的发生（OR：0.835、0.776 和 0.898）。对于 HOMA-IR 的预测，AMH 的 AUC-ROC 为 0.704（95% CI 0.652–0.755），临界值为 7.81 mmol/L，灵敏度为 70.3%，结论。较高的 AMH 水平与较低的胰岛素水平显着相关，并且可能是 PCOS 患者 HOMA-IR 的有用预测因子。