Colorectal cancer (CRC) is one of the common malignancies worldwide and the Wnt signaling pathway is recognized as the main disrupted pathway in this malignancy. MicroRNAs (miRNAs) are recognized to contribute to the pathogenesis of CRC by triggering or impeding the Wnt signaling pathway. In addition, transcriptional regulation of miRNAs by canonical Wnt signaling also participates in CRC cell progression. In this review, we present comprehensive literature of the existing data on the interaction of miRNAs and Wnt signaling that could be useful in future studies in the field of CRC management.

中文翻译：

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结直肠癌中的miRNA-Wnt信号调控网络

结直肠癌 (CRC) 是世界范围内常见的恶性肿瘤之一，Wnt 信号通路被认为是该恶性肿瘤的主要破坏通路。MicroRNAs (miRNAs) 被认为通过触发或阻碍 Wnt 信号通路促进 CRC 的发病机制。此外，经典 Wnt 信号对 miRNA 的转录调控也参与了 CRC 细胞的进程。在这篇综述中，我们提供了关于 miRNA 和 Wnt 信号相互作用的现有数据的综合文献，这些数据可能对 CRC 管理领域的未来研究有用。