Bronchial asthma is a common chronic inflammatory disease with high prevalence and morbidity, particularly in school-aged children. Decoy receptor 3 (DcR3) is a soluble decoy receptor that belongs to the tumor necrosis factor receptor superfamily and has been reported to be elevated in several allergic and inflammatory diseases. This study was designed to determine the role of DcR3 in pediatric asthma. The serum DcR3 levels were analyzed in 85 subjects (60 pediatric patients with bronchial asthma and 25 age- and sex-matched healthy control children) using the enzyme-linked immunosorbent assay technique. Patients with asthma had higher serum DcR3 levels than healthy control subjects (p = 0.007). In the atopic group of patients with asthma, the serum DcR3 levels were inversely correlated with the asthma control test score (R = − 0.392, p = 0.039). Overall, DcR3 could be a promising biomarker of atopic asthma, specifically in pediatric patients.

支气管哮喘是一种常见的慢性炎症性疾病，发病率和发病率都很高，尤其是在学龄儿童中。诱饵受体 3 (DcR3) 是一种可溶性诱饵受体，属于肿瘤坏死因子受体超家族，据报道在几种过敏和炎症疾病中升高。本研究旨在确定 DcR3 在儿童哮喘中的作用。使用酶联免疫吸附测定技术分析了 85 名受试者（60 名患有支气管哮喘的儿科患者和 25 名年龄和性别匹配的健康对照儿童）的血清 DcR3 水平。哮喘患者的血清 DcR3 水平高于健康对照组（p = 0.007)。在哮喘特应性患者组中，血清 DcR3 水平与哮喘控制测试评分呈负相关（R  = - 0.392，p  = 0.039）。总体而言，DcR3 可能是特应性哮喘的一个有前途的生物标志物，特别是在儿科患者中。