The diagnosis of drug-induced anaphylactic death is an important component of forensic medicine. The purpose of this study was to explore the expression of FcεRIα and tryptase in human lung tissue during drug-induced anaphylactic death and its value for forensic medicine. The expression of FcεRIα and tryptase in lung tissues of the drug-induced anaphylactic death group (n = 30) and control group (who died due to sudden cardiac death, falling from a height, or traffic accidents, n = 30) was detected by immunohistochemistry and immunofluorescence staining. The difference in FcεRIα and tryptase expression in the lung tissue between the drug-induced anaphylactic death group and the control group was statistically significant (p < 0.05). The levels of FcεRIα and tryptase expression greatly increased in the lung tissue of the drug-induced anaphylactic death group, which may provide morphological evidence and a reference for the diagnosis of drug-induced anaphylactic death in forensic medicine.

药物性过敏性死亡的诊断是法医学的重要组成部分。本研究旨在探讨药物性过敏性死亡过程中人肺组织中FcεRIα和类胰蛋白酶的表达及其法医学价值。药物性过敏性死亡组（n=30）和对照组（因心源性猝死、高处坠落、交通事故死亡，n=30）肺组织中FcεRIα和类胰蛋白酶的表达免疫组化和免疫荧光染色。药物性过敏性死亡组与对照组肺组织中FcεRIα和类胰蛋白酶表达的差异有统计学意义（p < 0.05）。