Repetitive transcranial magnetic stimulation (rTMS) of the brain is an effective clinical treatment for psychiatric disorders. Noninvasive neuroimaging during rTMS allows visualization of cortical brain activations and responses, and it is a potential tool for investigating the neurophysiological response occurring actively during stimulation. In this paper, we present a fast diffuse optical tomography (DOT) approach for three-dimensional brain mapping of hemodynamics during rTMS. Eight healthy subjects were enrolled in the study. These subjects received 10 Hz stimulation with 80%and 100%of resting motor threshold (rMT), respectively, for 4 seconds for each stimulation. Significant hemodynamic activation was observed in all cases with the strongest response when 100%rMT stimulation was applied. This work demonstrates that fast DOT has the potential to become a powerful tool for noninvasive three-dimensional imaging of the brain during rTMS.

中文翻译：

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经颅磁刺激过程中脑激活的三维光学成像

大脑的重复经颅磁刺激（rTMS）是治疗精神疾病的有效临床方法。rTMS 期间的非侵入性神经成像允许对大脑皮层的激活和反应进行可视化，它是研究在刺激过程中活跃发生的神经生理反应的潜在工具。在本文中，我们提出了一种快速扩散光学断层扫描 (DOT) 方法，用于 rTMS 期间的血流动力学三维脑映射。八名健康受试者参加了这项研究。这些受试者分别接受 80% 和 100% 的静息运动阈值 (rMT) 的 10 Hz 刺激，每次刺激持续 4 秒。当应用 100%rMT 刺激时，在所有反应最强的病例中都观察到显着的血流动力学激活。