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Silver Nanoparticles Induce Time- and Tissue-Specific Genotoxicity in Oreochromis niloticus: Utilizing the Adsorptive Capacities of Fruit Peels to Minimize Genotoxicity
Bulletin of Environmental Contamination and Toxicology ( IF 2.7 ) Pub Date : 2021-08-11 , DOI: 10.1007/s00128-021-03342-0
Amr Adel Abdel-Khalek 1 , Saleh Al-Quraishy 2 , Rewaida Abdel-Gaber 2
Affiliation  

Fish were exposed to a sub-lethal concentration of silver nanoparticles with and without orange and banana peels water treatment for 24, 48, and 96 h. The adsorption of AgNPs on both peels was recognized by scanning electron microscopic, energy dispersive X-ray spectroscopy, and laser ablation imaging. The % of DNA damage in liver and muscle tissues (comet assay) showed significant elevations in all studied groups with the maximum level in liver tissues after 24 h. DNA damage was markedly decreased after 48, and 96 h signifying the presence of an effective repairing mechanism. Micronucleus and nine nuclear anomalies were recorded in the peripheral blood cells. All anomalies were observed in all studied groups with a maximum induction rate after 96 h. of exposure. Based on the % of DNA damage and the frequencies of nuclear anomalies, water treatment with orange and banana peel succeeded to reduce AgNPs-induced genotoxic damage.



中文翻译:

银纳米颗粒诱导尼罗罗非鱼的时间和组织特异性基因毒性:利用果皮的吸附能力将基因毒性降至最低

鱼暴露于亚致死浓度的银纳米粒子,有或没有橙皮和香蕉皮水处理 24、48 和 96 小时。通过扫描电子显微镜、能量色散 X 射线光谱和激光烧蚀成像识别了 AgNPs 在两个果皮上的吸附。肝脏和肌肉组织中的 DNA 损伤百分比(彗星试验)在所有研究组中均显示显着升高,24 小时后肝脏组织中的水平最高。48 和 96 小时后 DNA 损伤明显减少,表明存在有效的修复机制。在外周血细胞中记录了微核和九个核异常。在所有研究组中观察到所有异常情况,96 小时后诱导率最大。的曝光。根据 DNA 损伤的百分比和核异常的频率,

更新日期:2021-08-11
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