Some Bacillus thuringiensis (Bt) strains produce dipteran-active toxins and can control larval mosquitoes. We identified a novel mosquitocidal toxin named Xpp81Aa1 with the thioredoxin domain from Bt strain HSY204. This toxin has very little sequence similarity to the three-domain Cry toxin and Cyt toxins and has significant toxicity to Aedes aegypti larvae. A safety assessment indicated that the Xpp81Aa1 toxin has no cytocidal activity against red blood cells and did not induce allergic reactions. The Xpp81Aa1 toxin exhibited a synergistic effect in combination with Cry2Aa and Cry4Aa protein toxins. Thus, the Xpp81Aa1 toxin could be a good candidate for mosquito control applications to reduce the mosquito-borne disease.

一些苏云金芽孢杆菌 (Bt) 菌株产生双翅目活性毒素，可以控制幼虫蚊子。我们从 Bt 菌株 HSY204 中鉴定了一种名为 Xpp81Aa1 的具有硫氧还蛋白结构域的新型杀蚊剂。这种毒素与三域 Cry 毒素和 Cyt 毒素几乎没有序列相似性，并且对埃及伊蚊幼虫具有显着的毒性。安全性评估表明 Xpp81Aa1 毒素对红细胞没有杀细胞活性，也不会引起过敏反应。Xpp81Aa1 毒素与 Cry2Aa 和 Cry4Aa 蛋白毒素组合时表现出协同作用。因此，Xpp81Aa1 毒素可能是蚊子控制应用的一个很好的候选者，以减少蚊子传播的疾病。