Objective

Children with attention-deficit/hyperactivity disorder (ADHD) show hypoactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Whether the association between hyperactivity/inattention symptoms with HPA axis dysfunction holds in the general child population too is not clear.

Method

We assessed associations between longitudinal trajectories of hyperactivity/inattention symptoms during ages 4 to 13 years and basal cortisol profiles at age 15 in a British general population cohort.

Results

Adolescents with persistently high levels of hyperactivity/inattention symptoms since childhood showed lower total morning cortisol and a smaller diurnal decline, even after adjusting for confounders. No associations were found between any of the symptom trajectories and cortisol awakening response, diurnal slope or daily output of cortisol.

Conclusion

This study provides evidence for hypocortisolism among adolescents with chronic hyperactivity/inattention symptoms in the general population.

中文翻译：

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青春期中期多动/注意力不集中症状和昼夜皮质醇的童年轨迹：来自英国出生队列的结果

客观的

患有注意力缺陷/多动障碍 (ADHD) 的儿童表现出下丘脑-垂体-肾上腺 (HPA) 轴的活动减退。多动/注意力不集中症状与 HPA 轴功能障碍之间的关联是否也存在于一般儿童人群中尚不清楚。

方法

我们评估了英国普通人群队列中 4 至 13 岁期间多动/注意力不集中症状的纵向轨迹与 15 岁时基础皮质醇曲线之间的关联。

结果

即使在调整了混杂因素后，自童年以来就持续存在高水平的多动/注意力不集中症状的青少年表现出较低的早晨皮质醇总量和较小的昼夜下降。没有发现任何症状轨迹与皮质醇觉醒反应、昼夜斜率或皮质醇每日输出量之间存在关联。

结论

这项研究为一般人群中患有慢性多动/注意力不集中症状的青少年的皮质醇减少症提供了证据。