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A Versatile Surgical Method for Studying Meniscus Implantation in a Rabbit Model
Tissue Engineering, Part C: Methods ( IF 2.7 ) Pub Date : 2021-08-18 , DOI: 10.1089/ten.tec.2021.0119
Guocheng Ding 1 , Guanying Gao 1 , Tong Wu 1 , Junyan Wang 1 , Xiaoqing Hu 1 , Xi Gong 1 , Yingfang Ao 1
Affiliation  

Meniscus injury is a health problem that greatly affects people's quality of life. In recent years, the number of diagnosed meniscus injury is increasing year by year. If not treated in time and correctly, it causes severe damages to the cartilage. Owing to the meniscus' limited healing ability, synthetic/tissue-engineered meniscus has emerged as a new treatment modality in recent years. Rabbit models, which have been proved to be a feasible animal model, have been extensively used to study meniscus implantation. However, there is not a unified and minimally invasive surgical method for meniscus implantation in rabbits, and the current surgical methods have unsolved problems, such as long incisions, patella valgus, and cutting of the medial collateral ligament. Therefore, the goal of this study is to provide a minimally invasive and versatile meniscus implantation method. Compared with the control group, our study showed less trauma to the animal model, and we believe that it has the application significance on tissue-engineered meniscus implantation.

中文翻译:

一种用于研究兔模型半月板植入的多功能手术方法

半月板损伤是严重影响人们生活质量的健康问题。近年来,半月板损伤确诊人数逐年增加。如果不及时正确治疗,会对软骨造成严重损害。由于半月板的愈合能力有限,近年来合成/组织工程化的半月板已成为一种新的治疗方式。兔模型已被证明是一种可行的动物模型,已广泛用于研究半月板植入。然而,兔半月板植入尚无统一的微创手术方法,目前手术方法存在切口长、髌骨外翻、内侧副韧带切断等问题。所以,本研究的目标是提供一种微创且通用的半月板植入方法。与对照组相比,我们的研究显示对动物模型的创伤较小,我们认为它在组织工程半月板植入术中具有应用意义。
更新日期:2021-08-21
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