Although autogenous demineralized dentin matrix (auto-DDM) has shown promising clinical and histological results, it has certain limitations beyond its osteoinductivity and osteoconductivity. Therefore, the application of dentin graft material from other individuals—allogeneic DDM (allo-DDM)—has been considered an alternative to auto-DDM. However, few studies have investigated the osteoinductivity and antigenicity of allo-DDM. Herein, we reviewed all human studies related to allogeneic dentin application for the management of maxillofacial bone defects. Clinical studies have shown the osteoinductivity of allo-DDM in extraskeletal and skeletal sites, regardless of occasional antigenicity.

中文翻译：

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同种异体牙本质移植治疗颌面骨缺损的回顾

尽管自体脱矿牙本质基质 (auto-DDM) 已显示出有希望的临床和组织学结果，但它除了其骨诱导性和骨传导性外，还具有一定的局限性。因此，应用来自其他个体的牙本质移植材料——同种异体 DDM (allo-DDM)——被认为是自动 DDM 的替代方案。然而，很少有研究调查allo-DDM的骨诱导性和抗原性。在此，我们回顾了所有与异基因牙本质应用治疗颌面骨缺损相关的人类研究。临床研究表明，allo-DDM 在骨骼外和骨骼部位具有骨诱导性，而与偶尔的抗原性无关。