A survey of functional dyspepsia in 361,360 individuals: Phenotypic and genetic cross-disease analyses,Neurogastroenterology & Motility

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A survey of functional dyspepsia in 361,360 individuals: Phenotypic and genetic cross-disease analyses
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2021-08-11 , DOI: 10.1111/nmo.14236
Koldo Garcia-Etxebarria _{1,

2,

3} , Florencia Carbone ₄ , Maris Teder-Laving ₅ , Anita Pandit ₆ , Lieselot Holvoet ₄ , Vincent Thijs ₇ , Robin Lemmens ₈ , Luis Bujanda _{1,

2,

9} , Andre Franke ₁₀ , Sebastian Zöllner _{6,

11} , Michael Boehnke ₆ , Matthew Zawistowski ₆ , Tonu Esko ₅ , Tack Jan ₄ , Mauro D'Amato _{1,

3,

12,

13}

Affiliation

Department of Gastrointestinal and Liver Diseases, Biodonostia Health Research Institute, San Sebastian, Spain.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd, Madrid, Spain.
Center for Molecular Medicine and Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Translational Research Center for GI Disorders (TARGID), University of Leuven, Leuven, Belgium.
Estonian Genome Center, University of Tartu, Tartu, Estonia.
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
Department of Neurosciences, Leuven Brain Institute (LBI), University of Leuven, Leuven, Belgium.
Universidad del País Vasco (UPV/EHU), San Sebastián, Spain.
Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain.

Functional dyspepsia (FD) is a common gastrointestinal condition of poorly understood pathophysiology. While symptoms’ overlap with other conditions may indicate common pathogenetic mechanisms, genetic predisposition is suspected but has not been adequately investigated.

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