Polytrauma is a major clinical problem due to its impact on morbidity and mortality, especially among the younger population. Its pathophysiology is not completely elucidated, and the study of the involvement of certain cell populations with therapeutic potential, such as mesenchymal stromal cells (MSCs), is an area of growing interest, as mesenchymal cells have anti-inflammatory, immunoregulatory, and osteogenic potential. In the present preliminary work, we have evaluated the characteristics of MSCs in terms of proliferation, immunophenotype, cell cycle, clonogenic capacity, and multilineage differentiation ability in a series of 18 patients with polytrauma and compared them to those from otherwise healthy patients undergoing elective spinal surgery. MSCs from polytrauma patients displayed higher proliferative potential with significantly higher cumulative population doublings, increased expression of some important cell adhesion molecules (CD105, CD166), and an early pre-osteogenic differentiation ability compared to those of the control group. MSCs could potentially be of help in the repair process of polytrauma patients contribute to both cell-tissue repair and anti-inflammatory response. This potential should be further explored in larger studies.

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来自多发伤患者的 MSCs：与来自择期手术患者的 MSCs 的初步比较研究

多发伤是一个主要的临床问题，因为它会影响发病率和死亡率，尤其是在年轻人群中。其病理生理学尚未完全阐明，并且由于间充质细胞具有抗炎、免疫调节和成骨潜力，因此对某些具有治疗潜力的细胞群（如间充质基质细胞 (MSC)）参与的研究是一个越来越受关注的领域. 在目前的初步工作中，我们评估了 18 名多发伤患者的 MSCs 在增殖、免疫表型、细胞周期、克隆形成能力和多向分化能力方面的特征，并将它们与接受选择性脊髓损伤的其他健康患者的特征进行了比较。外科手术。与对照组相比，来自多发伤患者的 MSC 显示出更高的增殖潜力，具有显着更高的累积群体倍增、一些重要细胞粘附分子（CD105、CD166）的表达增加以及早期成骨前分化能力。MSCs 可能有助于多发伤患者的修复过程，有助于细胞组织修复和抗炎反应。这种潜力应该在更大规模的研究中进一步探索。MSCs 可能有助于多发伤患者的修复过程，有助于细胞组织修复和抗炎反应。这种潜力应该在更大规模的研究中进一步探索。MSCs 可能有助于多发伤患者的修复过程，有助于细胞组织修复和抗炎反应。这种潜力应该在更大规模的研究中进一步探索。