First-degree relatives (FDRs) of people with rheumatoid arthritis (RA) have a fourfold increased risk of developing RA. The Symptoms in Persons At Risk of Rheumatoid Arthritis (SPARRA) questionnaire was developed to document symptoms in persons at risk of RA. The aims of this study were (1) to describe symptoms in a cohort of FDRs of patients with RA overall and stratified by seropositivity and elevated CRP and (2) to determine if patient characteristics were associated with symptoms suggestive of RA. A cross-sectional study of FDRs of patients with RA, in the PREVeNT-RA study, who completed a study questionnaire, provided a blood sample measured for rheumatoid factor, anti-CCP and CRP and completed the SPARRA questionnaire. Moderate/severe symptoms and symmetrical, small and large joint pain were identified and described. Symptoms associated with both seropositivity and elevated CRP were considered suggestive of RA. Logistic regression was used to determine if symptoms suggestive of RA were associated with patient characteristics. Eight hundred seventy participants provided all data, 43 (5%) were seropositive and 122 (14%) had elevated CRP. The most frequently reported symptoms were sleep disturbances (20.3%) and joint pain (17.9%). Symmetrical and small joint pain were 11.3% and 12.8% higher, respectively, in those who were seropositive and 11.5% and 10.7% higher in those with elevated CRP. In the logistic regression model, seropositivity, older age and feeling depressed were associated with increased odds of small and symmetrical joint pain. This is the first time the SPARRA questionnaire has been applied in FDRs of patients with RA and has demonstrated that the presence of symmetrical and small joint pain in this group may be useful in identifying people at higher risk of developing RA.

中文翻译：

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类风湿性关节炎患者一级亲属的症状：类风湿性关节炎风险人群症状横断面数据的评估 (SPARRA) RA 新靶点临床前评估 (PREVeNT-RA) 队列中的问卷

类风湿关节炎 (RA) 患者的一级亲属 (FDR) 患 RA 的风险增加四倍。类风湿性关节炎风险人群的症状 (SPARRA) 问卷旨在记录类风湿关节炎风险人群的症状。本研究的目的是 (1) 描述一组 RA 患者的 FDR 总体症状，并按血清阳性和升高的 CRP 进行分层，以及 (2) 确定患者特征是否与提示 RA 的症状相关。在 PREVeNT-RA 研究中，RA 患者的 FDR 横断面研究完成了研究问卷，提供了测量类风湿因子、抗 CCP 和 CRP 的血样，并完成了 SPARRA 问卷。确定并描述了中度/重度症状和对称的、小的和大的关节痛。与血清阳性和升高的 CRP 相关的症状被认为提示 RA。使用逻辑回归来确定提示 RA 的症状是否与患者特征相关。870 名参与者提供了所有数据，其中 43 名 (5%) 为血清阳性，122 名 (14%) 的 CRP 升高。最常报告的症状是睡眠障碍 (20.3%) 和关节痛 (17.9%)。对称性和小关节痛在血清阳性患者中分别高出 11.3% 和 12.8%，在 CRP 升高的患者中分别高出 11.5% 和 10.7%。在逻辑回归模型中，血清阳性、年龄较大和情绪低落与小关节和对称性关节疼痛的几率增加有关。