The complex cellular interactions that underlie pathologies related to reduced oxygen delivery after surgery are poorly defined and difficult to measure. Heywood and colleagues explored the patterns of protein expression in skin biopsies taken from a subgroup of patients enrolled in a randomised trial designed to evaluate perioperative goal-directed therapy. One of their key findings was that a failure of participants to maintain preoperative systemic oxygen delivery was associated with an upregulation of intracellular proteins involved in counteracting oxidative stress. Their study highlights the importance of oxidative stress in the perioperative setting and suggests that maintenance of baseline oxygen delivery might be an important regulator of redox balance.

与手术后氧输送减少相关的病理基础的复杂细胞相互作用定义不明确且难以测量。Heywood 及其同事探索了皮肤活检组织中蛋白质表达的模式，这些组织来自参与一项旨在评估围手术期目标导向治疗的随机试验的患者亚组。他们的主要发现之一是，参与者未能维持术前全身供氧与参与对抗氧化应激的细胞内蛋白质的上调有关。他们的研究强调了围手术期氧化应激的重要性，并表明维持基线氧输送可能是氧化还原平衡的重要调节剂。