Cell Death Discovery ( IF 6.1 ) Pub Date : 2021-08-11 , DOI: 10.1038/s41420-021-00596-9 Yan Liu 1 , Qiuyun Chen 1 , Yanan Zhu 1 , Tiying Wang 1 , Lijuan Ye 2 , Lei Han 1 , Zhihong Yao 1 , Zuozhang Yang 1
Distant metastasis is the main cause of death for cancer patients. Recently, the newly discovered programmed cell death includes necroptosis, pyroptosis, and ferroptosis, which possesses an important role in the process of tumor metastasis. At the same time, it is widely reported that non-coding RNA precisely regulates programmed death and tumor metastasis. In the present review, we summarize the function and role of necroptosis, pyrolysis, and ferroptosis involving in cancer metastasis, as well as the regulatory factors, including non-coding RNAs, of necroptosis, pyroptosis, and ferroptosis in the process of tumor metastasis.
中文翻译:
癌症转移中坏死性凋亡、细胞焦亡和铁死亡中的非编码 RNA
远处转移是癌症患者死亡的主要原因。最近,新发现的程序性细胞死亡包括坏死性凋亡、细胞焦亡和铁死亡,它们在肿瘤转移过程中具有重要作用。同时,广泛报道非编码RNA精确调节程序性死亡和肿瘤转移。在本综述中,我们总结了坏死性凋亡、热解和铁死亡在癌症转移中的功能和作用,以及肿瘤转移过程中坏死性凋亡、细胞焦亡和铁死亡的调节因子,包括非编码 RNAs。