The murburn precepts for cellular ionic homeostasis and electrophysiology,Journal of Cellular Physiology

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The murburn precepts for cellular ionic homeostasis and electrophysiology
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2021-08-11 , DOI: 10.1002/jcp.30547
Kelath Murali Manoj ₁ , Nikolai Bazhin ₂ , Hirohisa Tamagawa ₃

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Starting from the basic molecular structure and redox properties of its components, we build a macroscopic cellular electrophysiological model. We first present a murburn purview that could explain ion distribution in bulk-milieu/membrane-interface and support the origin of trans-membrane potential (TMP) in cells. In particular, the discussion focuses on how cells achieve disparity in the distribution of monovalent and divalent cations within (K⁺ > Na⁺ > Mg²⁺ > Ca²⁺) and outside (Na⁺ > K⁺ > Ca²⁺ > Mg²⁺). We explore how TMP could vary for resting/graded/action potentials generation and project a model for impulse conduction in neurons. Outcomes based on murburn bioenergetic equilibriums leading to solubilization of ion-pairs, membrane's permittivity, protein channels' fluxes, and proteins’ innate ability to bind/adsorb ions selectively are projected as the integral rationale. We also provide experimental modalities to ratify the projections.

中文翻译：

细胞离子稳态和电生理学的默本戒律

我们从其组分的基本分子结构和氧化还原性质入手，建立了宏观的细胞电生理模型。我们首先提出了一个 murburn 范围，它可以解释体环境/膜界面中的离子分布，并支持细胞中跨膜电位 (TMP) 的起源。特别是，讨论的重点是细胞如何在 (K ⁺ > Na ⁺ > Mg ²⁺ > Ca ²⁺ ) 和外部 (Na ⁺ > K ⁺ > Ca ²⁺ > Mg ^{2 ) 内实现一价和二价阳离子的分布差异。 +}）。我们探索 TMP 如何改变静息/分级/动作电位的产生，并为神经元中的脉冲传导设计一个模型。基于 murburn 生物能平衡导致离子对溶解、膜的介电常数、蛋白质通道的通量和蛋白质选择性结合/吸附离子的先天能力的结果被预测为整体原理。我们还提供实验方式来批准这些预测。

更新日期：2021-08-11

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