N-3 PUFA-Deficiency in Early Life Exhibits Aggravated MPTP-Induced Neurotoxicity in Old Age while Supplementation with DHA/EPA-Enriched Phospholipids Exerts a Neuroprotective Effect,Molecular Nutrition & Food Research

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N-3 PUFA-Deficiency in Early Life Exhibits Aggravated MPTP-Induced Neurotoxicity in Old Age while Supplementation with DHA/EPA-Enriched Phospholipids Exerts a Neuroprotective Effect
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2021-08-11 , DOI: 10.1002/mnfr.202100339
Fang Wu ₁ , Dan-Dan Wang ₁ , Hao-Hao Shi ₁ , Cheng-Cheng Wang ₁ , Chang-Hu Xue _{1,

2} , Yu-Ming Wang _{1,

2} , Tian-Tian Zhang ₁

Affiliation

Malnutrition in early life affects the growth and development of fetus and children, which has a long-term impact on adult health. Previous studies reveal a relationship between dietary omega-3 polyunsaturated fatty acid (n-3 PUFA) content, brain development, and the prevalence of neurodevelopmental disorders and inflammation. However, it is unclear about the effect of n-3 PUFA-deficiency in early life on the development of Parkinson's disease (PD) in old age, as well as the neuroprotective effect of DHA- and EPA-enriched phospholipids (DHA/EPA-PLs) supplemented in old age in long-term n-3 PUFA-deficient mice.

中文翻译：

早年 N-3 PUFA 缺乏症会加重 MPTP 诱导的老年神经毒性，而补充富含 DHA/EPA 的磷脂会发挥神经保护作用

生命早期的营养不良会影响胎儿和儿童的生长发育，对成人健康产生长期影响。先前的研究揭示了饮食中的 omega-3 多不饱和脂肪酸 (n-3 PUFA) 含量、大脑发育以及神经发育障碍和炎症的患病率之间的关系。然而，尚不清楚生命早期 n-3 PUFA 缺乏对老年帕金森病 (PD) 发展的影响，以及富含 DHA 和 EPA 的磷脂 (DHA/EPA- PLs）在长期缺乏 n-3 PUFA 的小鼠中在老年时补充。

更新日期：2021-10-20

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