OBJECTIVE Insulinomas are rare functional pancreatic neuroendocrine tumours. As previous data on the long-term prognosis of insulinoma patients are scarce, we studied the morbidity and mortality in the Finnish insulinoma cohort. DESIGN Retrospective cohort study. METHODS Incidence of endocrine, cardiovascular, gastrointestinal and psychiatric disorders, and cancers was compared in all the patients diagnosed with an insulinoma in Finland during 1980-2010 (n = 79, including two patients with multiple endocrine neoplasia type 1 syndrome), vs 316 matched controls, using the Mantel-Haenszel method. Overall survival was analysed with Kaplan-Meier and Cox regression analyses. RESULTS The median length of follow-up was 10.7 years for the patients and 12.2 years for the controls. The long-term incidence of atrial fibrillation (rate ratio (RR): 2.07 (95% CI: 1.02-4.22)), intestinal obstruction (18.65 (2.09-166.86)), and possibly breast (4.46 (1.29-15.39) and kidney cancers (RR not applicable) was increased among insulinoma patients vs controls, P < 0.05 for all comparisons. Endocrine disorders and pancreatic diseases were more frequent in the patients during the first year after insulinoma diagnosis, but not later on. The survival of patients with a non-metastatic insulinoma (n = 70) was similar to that of controls, but for patients with distant metastases (n = 9), the survival was significantly impaired (median 3.4 years). CONCLUSIONS The long-term prognosis of patients with a non-metastatic insulinoma is similar to the general population, except for an increased incidence of atrial fibrillation, intestinal obstruction, and possibly breast and kidney cancers. These results need to be confirmed in future studies. Metastatic insulinomas entail a markedly decreased survival.

中文翻译：

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诊断为胰岛素瘤的患者的长期发病率和死亡率。

目的 胰岛素瘤是罕见的功能性胰腺神经内分泌肿瘤。由于先前关于胰岛素瘤患者长期预后的数据很少，我们研究了芬兰胰岛素瘤队列的发病率和死亡率。设计回顾性队列研究。方法 比较 1980 年至 2010 年间在芬兰诊断为胰岛素瘤的所有患者（n = 79，包括两名患有多发性内分泌肿瘤 1 型综合征的患者）的内分泌、心血管、胃肠道和精神疾病以及癌症的发病率，与 316 名匹配控制，使用 Mantel-Haenszel 方法。使用 Kaplan-Meier 和 Cox 回归分析分析总生存期。结果 患者的中位随访时间为 10.7 年，对照组为 12.2 年。心房颤动的远期发生率（率比（RR）：2。这些结果需要在未来的研究中得到证实。转移性胰岛素瘤导致存活率显着降低。