Rationale: Near-Infrared persistent luminescence (NIR-PL) nanomaterials that can continually emit low-energy photons after ceasing excitation has emerged as a new generation of theranostic nanoparticle drug delivery systems (NDDSs) for imaging-guided cancer therapy, which stems from their special ability to completely avoid tissue autofluorescence interference. However, unresponsive diagnostic capability, inefficient drug delivery, and poor biodegradability limit the efficacy of most reported NIR-PL-based NDDSs./nMethods: Herein, a multifaceted tumor microenvironment (TME)-degradable theranostic drug delivery nanocapsule based on an ultrasmall persistent phosphor with a hollow mesoporous manganese-doped, DOX-loaded silica shell (Mn-ZGOCS-PEG) is developed to overcome the above drawbacks./nResults: We demonstrate that the well-designed nanocapsule enables tumor-responsive controlled drug release with ameliorated therapeutic efficacy, TME-responsive autofluorescence interference-free NIR-PL tracing, and manganese-enhanced magnetic resonance (Mn-MR) monitoring for practical dual-modality image-guided antitumor treatment in vivo./nConclusion: Our results indicate that Mn-ZGOCS-PEG nanocapsules enable tumor-targeting augmented chemotherapy under the guidance of TME-responsive dual-MR/NIR-PL-modality imaging in vivo. We believe that our work provides a new paradigm for the development of smart NIR-PL-based NDDSs with ultrasensitive multimodal diagnostic capability, enhanced anticancer effect, and efficient biodegradability.

中文翻译：

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可生物降解的锰工程纳米胶囊用于肿瘤敏感的近红外持续发光/磁共振成像和同步化疗


理由：近红外持久发光 (NIR-PL) 纳米材料在停止激发后能够持续发射低能光子，已成为用于成像引导癌症治疗的新一代治疗诊断纳米颗粒药物输送系统 (NDDS)，这源于其具有完全避免组织自发荧光干扰的特殊能力。然而，反应迟钝的诊断能力、低效的药物输送和较差的生物降解性限制了大多数报道的基于 NIR-PL 的 NDDS 的功效。开发了具有中空介孔锰掺杂、负载 DOX 的二氧化硅壳 (Mn-ZGOCS-PEG) 的荧光粉来克服上述缺点。/n结果：我们证明，精心设计的纳米胶囊能够实现肿瘤响应性受控药物释放，并改善治疗效果、TME 响应自发荧光无干扰 NIR-PL 示踪以及锰增强磁共振 (Mn-MR) 监测，用于实际双模态图像引导体内抗肿瘤治疗。/n结论：我们的结果表明，Mn- ZGOCS-PEG 纳米胶囊能够在体内TME 响应双 MR/NIR-PL 模态成像的指导下实现肿瘤靶向增强化疗。我们相信，我们的工作为开发基于 NIR-PL 的智能 NDDS 提供了新的范例，该 NDDS 具有超灵敏的多模式诊断能力、增强的抗癌效果和高效的生物降解性。