Iron is a critical component of many cellular functions including DNA replication and repair, and it is essential for cell vitality. As an essential element, iron is critical for maintaining human health. However, excess iron can be highly toxic, resulting in oxidative DNA damage. Many studies have observed significant associations between iron and cancer, and the association appears to be more than just coincidental. The chief characteristic of cancers, hyper-proliferation, makes them even more dependent on iron than normal cells. Cancer therapeutics are becoming as diverse as the disease itself. Targeting iron metabolism in cancer cells is an emerging, formidable field of therapeutics. It is a strategy that is highly diverse with regard to specific targets and the various ways to reach them. This review will discuss the importance of iron metabolism in cancer and highlight the ways in which it is being explored as the medicine of tomorrow.

中文翻译：

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在癌症治疗中靶向铁代谢

铁是许多细胞功能的关键组成部分，包括 DNA 复制和修复，它对细胞活力至关重要。作为一种必需元素，铁对维持人体健康至关重要。然而，过量的铁可能具有剧毒，导致氧化性 DNA 损伤。许多研究已经观察到铁与癌症之间的显着关联，而且这种关联似乎不仅仅是巧合。癌症的主要特征是过度增殖，这使得它们比正常细胞更依赖铁。癌症疗法正变得与疾病本身一样多样化。靶向癌细胞中的铁代谢是一个新兴的、强大的治疗领域。这是一种在具体目标和实现目标的各种方式方面高度多样化的战略。