Interleukin (IL)-1β is one of the major pathogenic regulators during the pathological development of intervertebral disc degeneration (IDD). However, effective treatment options for IDD are limited. Suramin is used to treat African sleeping sickness. This study aimed to investigate the pharmacological effects of suramin on mitigating IDD and to characterize the underlying mechanism.

中文翻译：

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苏拉明通过抑制 NF-κB 信号通路减轻椎间盘退变。

白细胞介素 (IL)-1β 是椎间盘退变 (IDD) 病理发展过程中的主要致病调节因子之一。然而，IDD 的有效治疗选择是有限的。苏拉明用于治疗非洲昏睡病。本研究旨在研究苏拉明减轻 IDD 的药理作用并确定其潜在机制。