There is a burgeoning body of evidence suggesting that arginine vasopressin (AVP) acts as a neuromodulator of the stress response. AVP stimulates the release of adrenocorticotropic hormone, synergistic to corticotropin-releasing hormone, which might explain AVP’s role in resilience. Personal hardiness is the bedrock of resilience. Numerous studies have demonstrated elevated plasma levels of AVP in patients with major depressive disorder (MDD), suggesting an etiopathogenetic role as well as a novel therapeutic target.

The aim of this study was to examine the relationship between AVP and resilience in patients with MDD and to determine AVP levels in serum of patients with MDD.

Forty patients with MDD and 40 healthy control subjects were studied using the Dispositional Resilience (Hardiness) Scale by Barton, the Quality of Life Scale, the Social Readjustment Rating Scale, and the Beck Depression Inventory. Biochemical analysis of plasma levels of AVP, using the enzyme-linked immunosorbent assay (ELISA), was performed for all participants.

Levels of AVP were statistically significantly elevated in patients with MDD compared with healthy controls. Psychological hardiness was decreased in patients with MDD compared with healthy controls, a finding also statistically significant. There was a negative correlation between plasma AVP level and psychological hardiness.

AVP and psychological hardiness are negatively correlated, reflecting lower stress resilience. AVP levels are indeed higher in patients struggling with MDD.

越来越多的证据表明精氨酸加压素 (AVP) 可作为应激反应的神经调节剂。AVP 刺激促肾上腺皮质激素的释放，与促肾上腺皮质激素释放激素协同作用，这可能解释了 AVP 在恢复力中的作用。个人坚韧是韧性的基石。大量研究表明，重度抑郁症 (MDD) 患者的 AVP 血浆水平升高，提示其发病机制和新的治疗靶点。

本研究的目的是检查 AVP 与 MDD 患者恢复力之间的关系，并确定 MDD 患者血清中的 AVP 水平。

40 名 MDD 患者和 40 名健康对照受试者使用 Barton 的性格弹性（坚韧）量表、生活质量量表、社会适应评定量表和贝克抑郁量表进行了研究。使用酶联免疫吸附测定 (ELISA) 对所有参与者进行了血浆 AVP 水平的生化分析。

与健康对照组相比，MDD 患者的 AVP 水平在统计学上显着升高。与健康对照组相比，重度抑郁症患者的心理韧性有所降低，这一发现也具有统计学意义。血浆AVP水平与心理韧性呈负相关。

AVP 和心理韧性呈负相关，反映出较低的压力恢复能力。患有 MDD 的患者的 AVP 水平确实更高。