Increased antimicrobial resistance demands the development of new antimicrobial agents with high potency. A wide variety of microbial systems are continuously subjected to mutations which ultimately results in antimicrobial resistance. The present study aimed at the fabrication of a nano drug delivery system which simultaneously is superparamagnetic, fluorescent, non-cytotoxic and antifungal. The developed system is an easily targetable and detectable tool owing to its superparamagnetic and fluorescent characteristics respectively. Superparamagnetic iron oxide nanoparticles stabilized by macromolecular starch have been incorporated into a fluorescently modified carrier system to get the final drug delivery system. The finally developed drug carrier system is found to be non-cytotoxic from the in vitro cytotoxicity studies performed against normal rat spleen cells. The photodynamic antifungal capability of the system was the premier concern of investigation of the present study. The antifungal studies were conducted against Histoplasma capsulatum and Trichophyton rubrum by well diffusion method and the results were compared with the activity of the antibiotic, griseofulvin. The minimum inhibitory concentration against each fungal strain was determined using broth dilution method. GRAPHIC ABSTRACT SUPPLEMENTARY INFORMATION The online version contains supplementary material available at 10.1007/s10570-021-04107-y.

中文翻译：

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超顺磁性和荧光药物载体系统对抗生素抗性真菌菌株的光动力抗真菌活性。

抗菌素耐药性的增加需要开发具有高效力的新型抗菌剂。各种各样的微生物系统不断发生突变，最终导致抗菌素耐药性。本研究旨在制造同时具有超顺磁性、荧光、无细胞毒性和抗真菌的纳米药物递送系统。由于其超顺磁性和荧光特性，所开发的系统是一种易于定位和检测的工具。由大分子淀粉稳定的超顺磁性氧化铁纳米颗粒已被掺入荧光改性的载体系统中，以获得最终的药物递送系统。对正常大鼠脾细胞进行的体外细胞毒性研究发现，最终开发的药物载体系统是无细胞毒性的。该系统的光动力抗真菌能力是本研究调查的首要关注点。采用井扩散法对荚膜组织胞浆菌和红色毛癣菌进行了抗真菌研究，并将结果与​​抗生素灰黄霉素的活性进行了比较。使用肉汤稀释法确定对每种真菌菌株的最小抑制浓度。图形摘要补充信息 在线版本包含可在 10.1007/s10570-021-04107-y 获得的补充材料。采用井扩散法对荚膜组织胞浆菌和红色毛癣菌进行了抗真菌研究，并将结果与​​抗生素灰黄霉素的活性进行了比较。使用肉汤稀释法确定对每种真菌菌株的最小抑制浓度。图形摘要补充信息 在线版本包含可在 10.1007/s10570-021-04107-y 获得的补充材料。采用井扩散法对荚膜组织胞浆菌和红色毛癣菌进行了抗真菌研究，并将结果与​​抗生素灰黄霉素的活性进行了比较。使用肉汤稀释法确定对每种真菌菌株的最小抑制浓度。图形摘要补充信息 在线版本包含可在 10.1007/s10570-021-04107-y 获得的补充材料。