INTRODUCTION The impact of chronic asthenia after thyroidectomy has been evaluated in two previous studies comparing total thyroidectomy and hemithyroidectomy. We compared its impact on patients undergoing thyroidectomy, parathyroidectomy for primary hyperparathyroidism, and cholecystectomy. METHODS Patients recruited for surgery (233 consecutive total thyroidectomies for non-toxic multinodular goiter, Group I, 43 consecutive parathyroidectomies for primary hyperparathyroidism, group II and a sample of 43 laparoscopic cholecystectomies, group III) were compared at three times: pre-operative, 6 months after surgery, 1 year after surgery. A brief fatigue inventory (BFI) was administered to assess asthenia. We excluded intermediate or high-risk thyroid carcinomas, Grave's disease, obese patients, secondary and tertiary hyperparathyroidism, vitamin D deficiency, and acute cholecystitis. In the postoperative period, patients who had undergone complications of each surgical procedure were also excluded. Demographics, smoking, alcohol abuse, chronic diseases (renal, cardiac, pulmonary, hepatic, and diabetes mellitus), anxiety and depression were noted. RESULTS In Group I the significant increase of asthenia during the three periods of detection (p < 0.001) was confirmed. Renal failure further increased the risk of asthenia. In Group II, asthenia after 6 months and 1 year after surgery decreased significantly (p < 0.001). In Group III, the variations in BFI during the three periods were not significant. CONCLUSIONS Asthenia is a frequent sequela of total thyroidectomy, also in comparison with other types of surgery. Patients undergoing thyroidectomy must be informed of the possible implications of surgery, which should be calibrated on the strict application of guidelines.

中文翻译：

---

接受内分泌颈部手术的患者的慢性虚弱。

引言 甲状腺切除术后慢性虚弱的影响已在之前的两项比较全甲状腺切除术和半甲状腺切除术的研究中进行了评估。我们比较了它对接受甲状腺切除术、原发性甲状旁腺功能亢进的甲状旁腺切除术和胆囊切除术的患者的影响。方法招募进行手术的患者（233 例无毒多结节性甲状腺肿连续全甲状腺切除术，第 I 组，43 例原发性甲状旁腺功能亢进症连续甲状旁腺切除术，第 II 组和 43 例腹腔镜胆囊切除术样本，第 III 组）在 3 次比较：术前，术后6个月，术后1年。进行了简短的疲劳清单 (BFI) 以评估虚弱。我们排除了中危或高危甲状腺癌、格雷夫病、肥胖患者、继发性和三发性甲状旁腺功能亢进症、维生素D缺乏症和急性胆囊炎。在术后期间，还排除了每个手术过程中出现并发症的患者。人口统计学、吸烟、酗酒、慢性疾病（肾、心脏、肺、肝和糖尿病）、焦虑和抑郁都被记录在案。结果 在第一组中，证实了在三个检测期（p < 0.001）期间虚弱的显着增加。肾功能衰竭进一步增加了虚弱的风险。在第 II 组中，术后 6 个月和 1 年的乏力显着下降（p < 0.001）。在第三组中，三个时期的 BFI 变化不显着。结论 乏力是甲状腺全切除术的常见后遗症，与其他类型的手术相比也是如此。