Highly absorbent alginate/polyethylene oxide submicron fibers containing the hydrophilic model drug tetracycline hydrochloride were prepared through centrifugal spinning. Pre-treatment with ethanol before crosslinking with calcium chloride solution maintained the structure of submicron fibers. The crosslinked submicron fibers could absorb phosphate buffer over 8 hours continuously, and they absorbed more phosphate buffer than commercial alginate dressing (Kaltostat and Algisite M). The morphology and chemical structures of submicron fibers were also investigated. In-vitro drug release tests revealed that more than 70 % (86 % 75 % and 73 % for drug loaded CA1, CA2 and CA3 fibers, respectively) of the loaded drug could be released continuously from the fibers in 24 hours, which matches well with the change frequency guidance of wound dressing for exuding wounds with heavy to moderate exudate. TCH loaded submicron fibers maintained the inhibition effect on Gram-positive S. aureus (31.25±0.71 mm (TCH-CA1), 30.85±0.27 mm (TCH-CA2) and 28.75±1.01 mm (TCH-CA3)) and Gram-negative E. coli. (29.8±0.35 mm (TCH-CA1), 29.28±0.87 mm (TCH-CA2) 27.38±0.64 mm (TCH-CA3)). These drug-loaded alginate submicron fibers may have application in wound dressing for exuding wounds.

通过离心纺丝制备了含有亲水模型药物盐酸四环素的高吸水性海藻酸盐/聚环氧乙烷亚微米纤维。在用氯化钙溶液交联之前用乙醇进行预处理保持了亚微米纤维的结构。交联的亚微米纤维可以连续吸收磷酸盐缓冲液超过 8 小时，并且它们比商业海藻酸盐敷料（Kaltostat 和 Algisite M）吸收更多的磷酸盐缓冲液。还研究了亚微米纤维的形态和化学结构。体外药物释放测试表明，超过 70%（载药 CA1、CA2 和 CA3 纤维分别为 86% 和 73%）的载药可以在 24 小时内从纤维中连续释放，与渗出液重至中度渗出伤口敷料更换频率指导相匹配。TCH负载亚微米纤维保持对革兰氏阳性菌的抑制作用金黄色葡萄球菌(31.25±0.71 mm (TCH-CA1)、30.85±0.27 mm (TCH-CA2) 和 28.75±1.01 mm (TCH-CA3)) 和革兰氏阴性大肠杆菌。(29.8±0.35 毫米 (TCH-CA1), 29.28±0.87 毫米 (TCH-CA2) 27.38±0.64 毫米 (TCH-CA3))。这些载药海藻酸盐亚微米纤维可用于渗出伤口的伤口敷料。