Novel roles of Tsukushi in signaling pathways and multiple disease processes

Xia Deng, Yanyan Li, Chang Guo, Zhicong Zhao and Guoyue Yuan

Tsukushi (TSK), a newly discovered hepatokine, belongs to the leucine rich proteoglycans (SLRPs) family. Previous studies have shown that TSK, as an extracellular signal mediator, can regulate a variety of signal pathways, including BMP, Wnt, TGF-β, FGF, and MAPK. Recently, more and more studies have found that TSK is involved in many diseases, such as obesity, diabetes, nonalcoholic fatty liver disease and tumor. This study summarizes novel roles of TSK in signaling pathways and multiple disease processes, expands people's understanding of the role and function of TSK gene, and provides a theoretical basis for further research.

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中文翻译：

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问题亮点

筑紫在信号通路和多种疾病过程中的新作用

邓夏、李艳艳、郭昌、赵志聪、袁国悦

Tsukushi (TSK) 是一种新发现的肝因子，属于富含亮氨酸的蛋白多糖 (SLRPs) 家族。以往的研究表明，TSK作为一种细胞外信号介质，可以调节多种信号通路，包括BMP、Wnt、TGF-β、FGF和MAPK。近年来，越来越多的研究发现TSK与肥胖、糖尿病、非酒精性脂肪肝、肿瘤等多种疾病有关。本研究总结了TSK在信号通路和多种疾病过程中的新作用，扩大了人们对TSK基因作用和功能的认识，为进一步研究提供了理论基础。

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