Tissue adhesives do not normally perform well on tissues that are covered with blood or other bodily fluids. Here we report the design, adhesion mechanism and performance of a paste that haemostatically seals tissues in less than 15 s, independently of the blood-coagulation rate. With a design inspired by barnacle glue (which strongly adheres to wet and contaminated surfaces owing to adhesive proteins embedded in a lipid-rich matrix), the paste consists of a blood-repelling hydrophobic oil matrix containing embedded microparticles that covalently crosslink with tissue surfaces on the application of gentle pressure. It slowly resorbs over weeks, sustains large pressures (approximately 350 mm Hg of burst pressure in a sealed porcine aorta), makes tough (interfacial toughness of 150–300 J m⁻²) and strong (shear and tensile strengths of, respectively, 40–70 kPa and 30–50 kPa) interfaces with blood-covered tissues, and outperforms commercial haemostatic agents in the sealing of bleeding porcine aortas ex vivo and of bleeding heart and liver tissues in live rats and pigs. The paste may aid the treatment of severe bleeding, even in individuals with coagulopathies.

组织粘合剂在被血液或其他体液覆盖的组织上通常不能很好地发挥作用。在这里，我们报告了在不到 15 秒的时间内止血密封组织的糊剂的设计、粘附机制和性能，与血液凝固率无关。设计灵感来自藤壶胶（由于嵌入富含脂质的基质中的粘性蛋白质，它强烈粘附在潮湿和受污染的表面上），这种糊状物由一种排斥血液的疏水油基质组成，该基质含有嵌入的微粒，这些微粒与组织表面共价交联应用温和的压力。它在数周内缓慢吸收，承受大压力（在密封的猪主动脉中大约 350 mm Hg 的爆裂压力），变得坚韧（150-300 J m ^{-2的界面韧性}) 和强（分别为 40-70 kPa 和 30-50 kPa 的剪切和拉伸强度）与血液覆盖组织的界面，并且在离体出血猪主动脉和出血心脏和肝脏组织的密封方面优于商业止血剂在活的大鼠和猪中。即使在患有凝血病的个体中，这种糊剂也可能有助于治疗严重出血。