The plasma membrane channel PANX1 mediates release of bio-active adenine nucleotides; however, its function in immune cells is unknown. In this issue of Immunity, Medina et al. show that PANX1 mediates adenosine-dependent communication between regulatory and effector CD4⁺ T cells during allergic airway inflammation.

中文翻译：

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会说话的 T 细胞让哮喘喘不过气来

质膜通道 PANX1 介导生物活性腺嘌呤核苷酸的释放；然而，其在免疫细胞中的功能尚不清楚。在本期Immunity中，Medina 等人。显示 PANX1 在过敏性气道炎症期间介导调节性和效应 CD4 ⁺ T 细胞之间的腺苷依赖性通讯。