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Triclosan-containing sutures: safety and resistance issues need to be addressed prior to generalized use
Applied Nanoscience ( IF 3.869 ) Pub Date : 2021-08-09 , DOI: 10.1007/s13204-021-01979-1
Raees Khan 1 , Adnan Haider 1 , Syed Babar Jamal 1 , Alyson L. Yee 2 , Jack A. Gilbert 3 , Fawad Muhammad 4
Affiliation  

Triclosan (TCS), a synthetic antimicrobial, has been incorporated into a variety of personal care products worldwide. Since 2016, upon the recommendation of World Health Organization (WHO), the use of TCS-containing sutures (TCSCS) to prevent surgical site infections (SSI) has become a common practice. However, TCS is a subject of environmental and public health concern and has been ranked as a chemical of serious concern to be avoided based on GreenScreen® hazard assessment. Recent reports on the efficacy of TCSCS to prevent SSI have revealed conflicting results. Here, we aim to highlight and discuss various safety and antimicrobial resistance concerns associated with the generalized use of TCSCS. Further, we emphasize that the long-term health benefits must be evaluated before the incorporation of TCS into surgical sutures.



中文翻译:

含三氯生的缝合线:普遍使用前需要解决安全性和耐药性问题

三氯生 (TCS) 是一种合成抗菌剂,已被纳入全球各种个人护理产品中。自 2016 年起,根据世界卫生组织 (WHO) 的建议,使用含 TCS 的缝线 (TCSCS) 来预防手术部位感染 (SSI) 已成为普遍做法。然而,TCS 是环境和公共健康问题的主题,并且已根据 GreenScreen ®被列为需要避免的严重关注的化学品危害评估。最近关于 TCSCS 预防 SSI 功效的报告揭示了相互矛盾的结果。在这里,我们旨在强调和讨论与广泛使用 TCSCS 相关的各种安全性和抗菌素耐药性问题。此外,我们强调在将 TCS 纳入手术缝合线之前必须评估长期健康益处。

更新日期:2021-08-10
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