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In Vivo CW-EPR Spectrometer Systems for Dosimetry and Oximetry in Preclinical and Clinical Applications
Applied Magnetic Resonance ( IF 1.1 ) Pub Date : 2021-08-07 , DOI: 10.1007/s00723-021-01382-7
Wilson Schreiber 1 , Sergey V. Petryakov 1 , Maciej M. Kmiec 1 , Ann Barry Flood 1 , Harold M. Swartz 1, 2 , Benjamin B. Williams 1, 2 , Philip E. Schaner 2
Affiliation  

EPR spectrometers (and various sub-systems) have been designed and constructed to facilitate in vivo measurements with human subjects for dosimetry and oximetry. Most applications are primarily focused on surface tissue measurements; however, oximetric measurements utilizing implantable devices are also discussed. Given various specifications and considerations across these two primary applications, several embodiments and configurations of the associated sub-systems to the spectrometer have been realized and implemented. These embodiments and configurations have been developed and tested with a focus on the end-use and the end-users. This includes acknowledgement of the challenges and needs for making measurements in unanesthetized human patients, the nature of the data that are most likely to be useful for clinical decision-making, and the person who will be making the actual measurements. Significant developments in spectrometer automation and features to ensure the quality of recorded data are featured.



中文翻译:

用于临床前和临床应用中的剂量测定和血氧测定的体内 CW-EPR 光谱仪系统

EPR 光谱仪(和各种子系统)已被设计和构建,以促进对人类受试者进行剂量测定和血氧测定的体内测量。大多数应用主要集中在表面组织测量;然而,也讨论了使用可植入设备的血氧测量。考虑到跨越这两个主要应用的各种规范和考虑,已经实现并实现了与光谱仪相关联的子系统的多个实施例和配置。这些实施例和配置的开发和测试着眼于最终用途和最终用户。这包括承认在未麻醉的人类患者中进行测量的挑战和需求,最有可能对临床决策有用的数据的性质,以及进行实际测量的人。光谱仪自动化和功能的重大发展,以确保记录数据的质量。

更新日期:2021-08-10
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