Sepsis, an inflammation-related clinical syndrome, is characterized by disrupted immune homeostasis accompanied by infection and multiple organ dysfunction as determined by the Sequential Organ Failure Assessment (SOFA). Substantial evidence has recently suggested that lncRNAs orchestrate various biological processes in diseases, and lncRNAs play special roles in the diagnosis and management of sepsis. To date, very few reviews have provided clear and comprehensive clues to demonstrate the roles of lncRNAs in the pathogenesis of sepsis. Based on previously published studies, in this review, we summarize the different functions of lncRNAs in sepsis-induced cellular disorders and sepsis-induced organ failure to show the potential roles of lncRNAs in the diagnosis and management of sepsis. We further depict the function of some lncRNAs known to be pivotal regulators in the pathogenesis of sepsis to discuss the underlying molecular events. Additionally, we list and discuss several hotspots in research on lncRNAs, which may be conducive to future lncRNA-targeted therapeutic approaches for sepsis treatment.

脓毒症是一种炎症相关的临床综合征，其特征是免疫稳态破坏，伴有感染和多器官功能障碍，由顺序器官衰竭评估 (SOFA) 确定。最近有大量证据表明 lncRNAs 协调疾病中的各种生物过程，lncRNAs 在败血症的诊断和管理中发挥特殊作用。迄今为止，很少有评论提供清晰而全面的线索来证明 lncRNA 在败血症发病机制中的作用。基于先前发表的研究，在本综述中，我们总结了 lncRNA 在败血症诱导的细胞疾病和败血症诱导的器官衰竭中的不同功能，以展示 lncRNA 在败血症诊断和管理中的潜在作用。我们进一步描述了一些已知是败血症发病机制中关键调节因子的 lncRNA 的功能，以讨论潜在的分子事件。此外，我们列出并讨论了lncRNAs研究中的几个热点，这可能有助于未来lncRNA靶向治疗脓毒症的治疗方法。