Psoriasis is a chronic, immune-mediated inflammatory skin disease characterized by abnormal T cell activation and excessive proliferation of keratinocytes. In addition to skin manifestations, psoriasis has been associated with multiple metabolic comorbidities, such as obesity, insulin resistance, and diabetes. An increasing amount of evidence has highlighted the core role of adipokines in adipose tissue and the immune system. This review focus on the role of adiponectin in the pathophysiology of psoriasis and its comorbidities, highlighting the future research avenues.

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脂联素在银屑病及其合并症中的应用：综述

银屑病是一种慢性、免疫介导的炎症性皮肤病，其特征是 T 细胞活化异常和角质形成细胞过度增殖。除了皮肤表现外，银屑病还与多种代谢合并症有关，例如肥胖、胰岛素抵抗和糖尿病。越来越多的证据强调了脂肪因子在脂肪组织和免疫系统中的核心作用。本综述重点关注脂联素在银屑病及其合并症病理生理学中的作用，突出未来的研究途径。