ABSTRACT

Bioconversion can enhance the functionality of efficacy. We made bioconversion material with black rice (Oryza sativa L.) and blueberry (Vaccinium crymbosum L.), using Lactobacillus plantarum (call BB). In this study, BB investigated anti-inflammatory and immune-boosting effects through immune system control. Therefore, we investigated the efficacy of BB in the presence and absence of LPS (Lipopolysaccharide). In the presence of LPS, the bioconversion material inhibited nitric oxide (NO) production from LPS in macrophages, inhibited inducible nitric oxide synthase (iNOS), Cyclooxygenase 2 (COX-2), phosphorylation of mitogen-activated protein kinases (such as JNK, ERK and p-38) and reduced the secretion of cytokines Tumor necrosis factor-α (TNF-α) and Interleukin-6 (IL-6). In the absence of LPS, BB exhibited an effect that was opposite of LPS stimulation. These data show that the effect was lower than that of LPS. In conclusion, BB suggested that anti-inflammatory and immune-boosting effects through the regulation of the immune system are multi-efficacy materials.

摘要

生物转化可以增强功效的功能。我们用黑米 ( Oryza sativa L. ) 和蓝莓 ( Vaccinium crmbosum L. )制作生物转化材料，使用植物乳杆菌（呼叫BB）。在这项研究中，BB 通过免疫系统控制研究了抗炎和增强免疫的作用。因此，我们研究了 BB 在存在和不存在 LPS（脂多糖）的情况下的功效。在 LPS 存在下，生物转化材料抑制巨噬细胞中 LPS 产生一氧化氮 (NO)，抑制诱导型一氧化氮合酶 (iNOS)、环氧合酶 2 (COX-2)、丝裂原活化蛋白激酶（如 JNK、 ERK 和 p-38) 并减少细胞因子肿瘤坏死因子-α (TNF-α) 和白细胞介素-6 (IL-6) 的分泌。在没有 LPS 的情况下，BB 表现出与 LPS 刺激相反的效果。这些数据表明效果低于LPS。综上所述，