Combined photothermal-immunotherapy via poly-tannic acid coated PLGA nanoparticles for cancer treatment,Biomaterials Science

当前位置： X-MOL 学术 › Biomater. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Combined photothermal-immunotherapy via poly-tannic acid coated PLGA nanoparticles for cancer treatment
Biomaterials Science ( IF 5.8 ) Pub Date : 2021-07-27 , DOI: 10.1039/d1bm00474c
Xingyue Huang ₁ , Xuehao Tian ₁ , Qing Zhang ₁ , Haiyan Hu ₁ , Jiahui Gao ₁ , Baonan Ma ₁ , Kai Wu ₁ , Jie Bai ₁ , Shouying Du ₁ , Yang Lu ₁ , Ning Han ₁

Affiliation

Photothermal therapy (PTT) is able to ablate tumors via hyperthermia, while immunotherapy could prevent tumor recurrence and metastasis by activating the host immune responses. Therefore, the combination of PTT and immunotherapy offers great advantages for the treatment of cancer. To achieve this goal, poly tannic acid (pTA) coated PLGA nanoparticles (PLGA-pTA NPs) were synthesized for combined photothermal-immunotherapy. pTA was a coordination complex formed by TA and Fe³⁺ and it could be easily coated on PLGA NPs within seconds with a coating rate of 5.89%. As a photothermal agent, PLGA-pTA revealed high photothermal conversion efficiency and excellent photo-stability upon 808 nm laser irradiation. It also exhibited strong photothermal cytotoxicity against 4T1 cells. Moreover, PLGA-pTA based PTT could effectively trigger DC maturation since it could induce the release of DAMPs. The result of animal experiments showed that PLGA-pTA plus laser irradiation raised the tumor temperature up to ca. 60 °C and effectively suppressed the growth of primary tumors. What's more, the progression of distant tumors as well as lung metastasis was also significantly inhibited due to the activation of anti-tumor responses by PLGA-pTA mediated PTT. When further combined with anti-PD-L1 antibody (a-PD-L1), the tumor growth and metastasis were almost completely inhibited. Our study provided a versatile platform to achieve combined photothermal-immunotherapy with enhanced therapeutic efficacy.

中文翻译：

聚单宁酸包覆PLGA纳米粒子联合光热免疫疗法用于癌症治疗

光热疗法（PTT）能够通过热疗消融肿瘤，而免疫疗法可以通过激活宿主免疫反应来防止肿瘤复发和转移。因此，PTT与免疫疗法的结合为癌症的治疗提供了巨大的优势。为了实现这一目标，合成了聚单宁酸 (pTA) 涂层的 PLGA 纳米粒子 (PLGA-pTA NPs) 用于联合光热免疫疗法。pTA 是由 TA 和 Fe ³⁺形成的配位络合物它可以在几秒钟内轻松地涂覆在 PLGA NPs 上，涂覆率为 5.89%。作为光热剂，PLGA-pTA 在 808 nm 激光照射下显示出高光热转换效率和优异的光稳定性。它还对 4T1 细胞表现出强烈的光热细胞毒性。此外，基于 PLGA-pTA 的 PTT 可以有效地触发 DC 成熟，因为它可以诱导 DAMP 的释放。动物实验结果表明，PLGA-pTA 加激光照射可使肿瘤温度升高至约。60°C并有效抑制原发肿瘤的生长。此外，由于PLGA-pTA介导的PTT激活了抗肿瘤反应，远处肿瘤的进展以及肺转移也被显着抑制。当进一步结合抗PD-L1抗体（a-PD-L1）时，肿瘤的生长和转移几乎被完全抑制。我们的研究提供了一个多功能平台，可以实现光热免疫联合治疗并提高治疗效果。

更新日期：2021-08-10

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11