This study investigated the effects of intrauterine growth restriction during late pregnancy on the ovine fetal renal function and renal antioxidant capacity. Eighteen ewes pregnant were randomly divided into control group (CG, ad libitum, 0.67 MJ ME·BW^−0.75·day⁻¹, n = 6), restricted group 1 (RG1, 0.18 MJ ME·BW^−0.75·day⁻¹, n = 6), and restricted group 2 (RG2, 0.33 MJ ME·BW^−0.75·day⁻¹, n = 6). At 140 days, the fetal blood, allantoic fluid and kidney tissue were collected to determinate fetal renal function and renal antioxidant capacity. The results showed that the fetal weight, kidney weight, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), aquaporin-2 (AQP-2) and aquaporin-3 (AQP-3), and total antioxidant capacity (T-AOC) in RG1 group were decreased compared with the CG (P < 0.05), but the contents of β2-Microglobulin (β 2-MG), cystatin C (Cys-C), filtered sodium excretion fraction (FENa), malondialdehyde (MDA), and hydroxyl radical (OH) in RG1 group were increased (P < 0.05). The impaired ovine fetal renal growth, antioxidant imbalance and dysfunction of glomerulus ultrafiltration, and the renal tubules reabsorption were induced by maternal malnutrition during late pregnancy.

中文翻译：

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妊娠晚期宫内生长受限对绵羊胎肾功能及抗氧化能力的影响

本研究探讨妊娠晚期宫内生长受限对绵羊胎儿肾功能和肾脏抗氧化能力的影响。18只怀孕母羊随机分为对照组（CG，随意，0.67 MJ ME·BW ^-0.75 ·day ^-1，n  = 6），限制组1（RG1，0.18 MJ ME·BW ^-0.75 ·day ^-1，n  = 6), 限制组 2 (RG2, 0.33 MJ ME·BW ^−0.75 ·day ⁻¹ , n = 6). 140天时，采集胎儿血液、尿囊液和肾组织，测定胎儿肾功能和肾脏抗氧化能力。结果显示，胎儿体重、肾脏重量、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、水通道蛋白2（AQP-2）和水通道蛋白3（AQP-3）、总抗氧化能力（T- RG1组AOC）较CG降低（P  < 0.05），但β2-微球蛋白（β2-MG）、胱抑素C（Cys-C）、滤过钠排泄分数（FENa）、丙二醛（MDA） ), RG1组羟基自由基(OH)增加( P < 0.05)。妊娠晚期母体营养不良导致绵羊胎儿肾脏生长受损、抗氧化失衡和肾小球超滤功能障碍以及肾小管重吸收。