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Inhibition of neuronal necroptosis mediated by RIP1/RIP3/MLKL provides neuroprotective effects on kaolin-induced hydrocephalus in mice
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-08-09 , DOI: 10.1111/cpr.13108
Chang Liu 1 , Yaxing Chen 1 , Wenyao Cui 1 , Yi Cao 1, 2 , Long Zhao 1 , Haoxiang Wang 1 , Xiaoyin Liu 1 , Shuangmin Fan 1 , Keru Huang 1 , Aiping Tong 3 , Liangxue Zhou 1
Affiliation  

Necroptosis is widespread in neurodegenerative diseases. Here, we examined necroptosis in the hippocampus and cortex after hydrocephalus and found that a necroptosis pathway inhibitor alleviates necroptosis and provides neuroprotective effects.

中文翻译:

抑制 RIP1/RIP3/MLKL 介导的神经元坏死性凋亡,对高岭土诱导的小鼠脑积水具有神经保护作用

坏死性凋亡在神经退行性疾病中广泛存在。在这里,我们检查了脑积水后海马和皮质的坏死性凋亡,发现坏死性凋亡途径抑制剂可以减轻坏死性凋亡并提供神经保护作用。
更新日期:2021-09-20
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