Expansion of CD45RA−FOXP3++ regulatory T cells is associated with immune tolerance in patients with combined kidney and bone marrow transplantation,Clinical & Translational Immunology

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Expansion of CD45RA−FOXP3++ regulatory T cells is associated with immune tolerance in patients with combined kidney and bone marrow transplantation
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2021-08-09 , DOI: 10.1002/cti2.1325
Yeongbeen Kwon _{1,

2} , Kyo Won Lee _{2,

3} , You Min Kim ₄ , Hyojun Park _{2,

5,

6} , Min Kyung Jung ₄ , Young Joon Choi _{4,

7} , Jin Kyung Son _{2,

6} , JuHee Hong ₂ , Su-Hyung Park ₄ , Ghee Young Kwon ₈ , Heejin Yoo ₉ , Kyunga Kim _{9,

10} , Sung Joo Kim _{2,

5,

6} , Jae Berm Park _{1,

2,

3} , Eui-Cheol Shin ₄

Affiliation

Samsung Advanced Institute for Health Sciences & Technology (SAIHST) Graduate School Department of Health Sciences & Technology Sungkyunkwan University Seoul Korea.
Transplantation Research Center Samsung Medical Center Samsung Biomedical Research Institute Seoul Korea.
Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.
Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Korea.
Department of Medicine Sungkyunkwan University School of Medicine Suwon Korea.
GenNbio Inc. Seoul Korea.
Department of Ophthalmology Ajou University School of Medicine Suwon Korea.
Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.
Statistics and Data Center Samsung Medical Center Research Institute for Future Medicine Seoul Korea.
Department of Digital Health Samsung Advanced Institute for Health Sciences & Technology Sungkyunkwan University Seoul Korea.

Simultaneous transplantation of a solid organ and bone marrow from the same donor is a possible means of achieving transplant tolerance. Here, we attempted to identify biomarkers that indicate transplant tolerance for discontinuation of immunosuppressants in combined kidney and bone marrow transplantation (CKBMT).

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