Gold-loaded nanoparticles are versatile nanomaterials that may be used in wound healing properties. The current study describes a wound dressing formulation focused on Gold-loaded Dextran/Silk Sericin nanoparticles. The Gold-loaded Dextran/Silk Sericin membranes were fabricated using Gold solutions inside the Dextran/Silk Sericin medium. The influence of various experimental conditions on Dextran/Silk Sericin nanoparticle formations were examined. The sizes of Dextran/Silk Sericin and Gold@Dextran/Silk Sericin nanoparticles were examined through the HR-SEM. Moreover, the efficacy antibacterial activity of Dextran/Silk Sericin and Gold-loaded Dextran/Silk Sericin nanoparticles was evaluated against the microorganisms gram-positive and negative. Furthermore, we observed the in vivo wound healing of wounds in skin using a mice model over a 16 days period. In this difference to the wounds of untreated mouse, quick healing was observed in the Gold-loaded Dextran/Silk Sericin nanoparticles-treated wounds with fewer injury. These results specify that Gold-loaded Dextran/Silk Sericin nanoparticles-based dressing material could be a ground-breaking nanomaterial having wound repair and implantations potential required for wound damages, which was proven using an animal model.

载金纳米粒子是多功能纳米材料，可用于伤口愈合特性。目前的研究描述了一种专注于载金葡聚糖/丝胶纳米粒子的伤口敷料配方。载金葡聚糖/丝胶蛋白膜是在葡聚糖/丝胶蛋白介质中使用金溶液制造的。检查了各种实验条件对葡聚糖/丝胶纳米颗粒形成的影响。通过 HR-SEM 检查葡聚糖/丝胶和 Gold@Dextran/丝胶纳米颗粒的尺寸。此外，还评估了葡聚糖/丝胶和载金葡聚糖/丝胶纳米颗粒对革兰氏阳性和阴性微生物的抗菌活性。此外，我们使用小鼠模型在 16 天的时间内观察了皮肤伤口的体内伤口愈合。在这种与未治疗小鼠伤口的差异中，在负载金葡聚糖/丝胶纳米粒子治疗的伤口中观察到快速愈合，损伤较少。这些结果表明，基于载金葡聚糖/丝胶纳米颗粒的敷料材料可能是一种突破性的纳米材料，具有伤口损伤所需的伤口修复和植入潜力，这一点已通过动物模型得到证实。