• Theranostic agent 1 (TA1) was successfully developed to provide dual functions: anti-inflammatory therapy and precise diagnosis.

• TA1 selectively reacts with H₂S_n in the mitochondria in response to inflammatory reactions to simultaneously produce both indomethacin as a drug and ring-opened fluorescence-on Rhodol.

• Theranostic behavior of TA1 was proven by in vitro and in vivo imaging.

• TA1 reveals inflammatory site-selective drug release followed by significant therapeutic effects and is highly applicable in vivo model therapeutics for the inflammatory disease.

中文翻译：

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线粒体 H2Sn 介导的抗炎治疗学

• Theranostic agent 1 ( TA1 ) 成功开发，具有双重功能：抗炎治疗和精准诊断。

• TA1选择性地与线粒体中的 H ₂ Sn反应以响应炎症反应，同时产生作为药物的吲哚美辛和 Rhodol 上的开环荧光_。

• 体外和体内成像证实了TA1的治疗诊断行为。

• TA1揭示了炎症部位选择性药物释放，随后具有显着的治疗效果，并且高度适用于炎症性疾病的体内模型治疗。