Abstract

PCV2 is the primary etiological agent of porcine circovirus-associated diseases (PCVADs) which affect pigs worldwide. Currently, there is a worldwide genotype prevalence switch from PCV2b to PCV2d, which has led to increased virulence of the circulating virus strains leading to vaccine failures and selection pressure. In the present study, the PCV2 genotypes circulating in north eastern region (NER) of India particularly the states of Assam and Arunachal Pradesh was characterized by isolation, sequencing and phylogenetic analysis of cap gene. The phylogenetic analysis revealed that the PCV2 isolates circulating in pigs of Assam and Arunachal Pradesh were mostly of PCV2d genotype. Hence, it can be concluded that PCV2d genotype is the most dominating genotype in NER and priority should be given to this genotype for development of future vaccine candidate against PCV2 in India.

摘要

PCV2 是影响全世界猪的猪圆环病毒相关疾病 (PCVAD) 的主要病原体。目前，世界范围内存在从 PCV2b 到 PCV2d 的基因型流行转变，这导致循环病毒株的毒力增加，从而导致疫苗失败和选择压力。在本研究中，在印度东北部地区 (NER) 尤其是阿萨姆邦和阿鲁纳恰尔邦流行的 PCV2 基因型的特征在于cap的分离、测序和系统发育分析基因。系统发育分析表明，在阿萨姆邦和阿鲁纳恰尔邦的猪中传播的 PCV2 分离株主要是 PCV2d 基因型。因此，可以得出结论，PCV2d 基因型是 NER 中最主要的基因型，在印度开发针对 PCV2 的未来候选疫苗时应优先考虑该基因型。