Objective Aortic valve calcification (AVC) and coronary artery calcification (CAC) are predictors of cardiovascular disease (CVD), presumably sharing risk factors. Our objectives were to determine the prevalence and extent of AVC in a large population of men aged 60–74 years and to assess the association between AVC and cardiovascular risk factors including CAC and biomarkers. Methods Participants from the DANish CArdioVAscular Screening and intervention trial (DANCAVAS) with AVC and CAC scores and without previous valve replacement were included in the study. Calcification scores were calculated on non-contrast CT scans. Cardiovascular risk factors were self-reported, measured or both, and further explored using descriptive and regression analysis for AVC association. Results 14 073 men aged 60–74 years were included. The AVC scores ranged from 0 to 9067 AU, with a median AVC of 6 AU (IQR 0–82). In 8156 individuals (58.0%), the AVC score was >0 and 215 (1.5%) had an AVC score ≥1200. In the regression analysis, all cardiovascular risk factors were associated with AVC; however, after inclusion of CAC ≥400, only age (ratio of expected counts (REC) 1.07 (95% CI 1.06 to 1.09)), hypertension (REC 1.24 (95% CI 1.09 to 1.41)), obesity (REC 1.34 (95% CI 1.20 to 1.50)), known CVD (REC 1.16 (95% CI 1.03 to 1.31)) and serum phosphate (REC 2.25 (95% CI 1.66 to 3.10) remained significantly associated, while smoking, diabetes, hyperlipidaemia, estimated glomerular filtration rate and serum calcium were not. Conclusions AVC was prevalent in the general population of men aged 60–74 years and was significantly associated with all modifiable cardiovascular risk factors, but only selectively after adjustment for CAC ≥400 AU. Trial registration number [NCT03946410][1] and [ISRCTN12157806][2]. Data are available on reasonable request. Study data were collected and managed using REDCap data management, hosted at the Odense Patient data Explorative Network. [1]: http://NCT03946410 [2]: http://ISRCTN12157806

中文翻译：

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丹麦老年男性主动脉瓣钙化和心血管危险因素的横断面研究

目的主动脉瓣钙化 (AVC) 和冠状动脉钙化 (CAC) 是心血管疾病 (CVD) 的预测因子，可能具有共同的风险因素。我们的目标是确定大量 60-74 岁男性人群中 AVC 的患病率和范围，并评估 AVC 与心血管危险因素（包括 CAC 和生物标志物）之间的关联。方法 来自丹麦心脏血管筛查和干预试验 (DANCAVAS) 的参与者包括 AVC 和 CAC 评分且之前没有瓣膜置换术。在非对比 CT 扫描中计算钙化评分。心血管危险因素是自我报告、测量或两者兼而有之，并使用描述性和回归分析进一步探索 AVC 关联。结果 共纳入 14 073 名 60-74 岁男性。AVC 评分范围为 0 到 9067 AU，平均 AVC 为 6 AU（IQR 0-82）。在 8156 人 (58.0%) 中，AVC 评分 >0，215 人 (1.5%) 的 AVC 评分≥1200。在回归分析中，所有心血管危险因素都与 AVC 相关；然而，在纳入 CAC ≥400 后，只有年龄（预期计数比 (REC) 1.07（95% CI 1.06 至 1.09））、高血压（REC 1.24（95% CI 1.09 至 1.41））、肥胖（REC 1.34（95 % CI 1.20 至 1.50))、已知 CVD（REC 1.16（95% CI 1.03 至 1.31））和血清磷酸盐（REC 2.25（95% CI 1.66 至 3.10）仍然显着相关，而吸烟、糖尿病、高脂血症、估计肾小球滤过率率和血清钙不是。结论 AVC 在 60-74 岁的一般男性人群中普遍存在，并且与所有可改变的心血管危险因素显着相关，但仅在调整 CAC ≥400 AU 后选择性地进行。试验注册号 [NCT03946410][1] 和 [ISRCTN12157806][2]。可应合理要求提供数据。研究数据是使用 REDCap 数据管理收集和管理的，托管在欧登塞患者数据探索网络上。[1]：http://NCT03946410 [2]：http://ISRCTN12157806