It has been observed in vitro that complete clot lysis is generally preceded by a slow phase of lysis during which the degradation seems to be inefficient. However, this slow regime was merely noticed, but not yet quantitatively discussed. In our experiments, we observed that the lysis ubiquitously occurred in two distinct regimes, a slow and a fast lysis regime. We quantified extensively the duration of these regimes for a wide spectrum of experimental conditions and found that on average, the slow regime lasts longer than the fast one, meaning that during most of the process, the lysis is ineffective. We proposed a computational model in which the properties of the binding of the proteins change during the lysis: first, the biochemical reactions take place at the surface of the fibrin fibers, then in the bulk, resulting in the observed fast lysis regime. This simple hypothesis appeared to be sufficient to reproduce with a great accuracy the lysis profiles obtained experimentally.

已在体外观察到，完全凝块溶解之前通常有一个缓慢的溶解阶段，在此期间降解似乎是低效的。然而，这种缓慢的制度只是被注意到，但尚未定量讨论。在我们的实验中，我们观察到裂解普遍发生在两种不同的状态下，即慢速和快速裂解状态。我们在广泛的实验条件下广泛量化了这些方案的持续时间，发现平均而言，慢速方案比快速方案持续时间更长，这意味着在大多数过程中，裂解是无效的。我们提出了一个计算模型，其中蛋白质结合的性质在裂解过程中发生变化：首先，生化反应发生在纤维蛋白纤维的表面，然后在本体中，导致观察到的快速裂解方案。这个简单的假设似乎足以高精度地再现实验获得的裂解曲线。