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Dielectric response to thermal denaturation of lenses in healthy and diabetic rabbits
Bioelectrochemistry ( IF 4.8 ) Pub Date : 2021-08-09 , DOI: 10.1016/j.bioelechem.2021.107923
E Marzec 1 , J Olszewski 1
Affiliation  

The relative permittivity and conductivity of healthy and alloxane-induced diabetic rabbits lenses were measured over a frequency range of 500 Hz to 100 kHz in an electric field and at temperatures from 25 to 150 °C. The dielectric spectra for both tissues showed two separate relaxations with a characteristic frequency of around 4 and 25 kHz assigned to the cortical and nuclear zones, respectively. These two dispersions are due to the interfacial polarization at the surface of the α-crystallin molecules. The denaturation temperature for the non-diabetic lens and the diabetic lens is approximately 70 and 80 °C, respectively. Moreover, the relative permittivity and conductivity values are higher in the diabetic lens than in the non-diabetic tissue at the same temperature and frequency. Our dielectric studies provide a better understanding of the thermal stability of crystallin-water complexes in normal and diseased human lenses.



中文翻译:

健康和糖尿病兔晶状体热变性的介电反应

在 500 Hz 至 100 kHz 的频率范围内,在电场和 25 至 150 °C 的温度下测量健康和四氧嘧啶诱导的糖尿病兔晶状体的相对介电常数和电导率。两种组织的介电光谱显示出两个独立的弛豫,其特征频率分别为约 4 kHz 和 25 kHz,分别分配给皮层和核区。这两种分散体是由于 α-晶状体蛋白分子表面的界面极化。非糖尿病镜片和糖尿病镜片的变性温度分别约为 70 和 80 °C。此外,在相同温度和频率下,糖尿病晶状体的相对介电常数和电导率值高于非糖尿病组织。

更新日期:2021-08-10
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